CAS NO. |
Products Name |
426219-18-3 |
TAK-700 (Orteronel) |
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TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). Phase 3. |
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507475-17-4 |
TPCA-1 |
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TPCA-1 is an inhibitor of IKK-2 with IC50 of 17.9 nM, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. |
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1025065-69-3 |
SGI-1776 |
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SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3, also potent to Flt3 and haspin. Phase 1. |
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SGC-CBP30 |
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SGC-CBP30 is a potent CREBBP/EP300 inhibitor with IC50 of 21 nM and 38 nM, respectively. |
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936563-96-1 |
Ibrutinib (PCI32765) |
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Ibrutinib is a potent and highly selective Btk inhibitor with IC50 of 0.5 nM, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. |
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1196109-52-0 |
PF3845 |
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PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2. |
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717907-75-0 |
PF562271 |
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PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. |
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4382-63-2 |
PFK-15 |
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PFK15 is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) with IC50 of 207 nM. |
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188591-46-0 |
GSK3787 |
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GSK3787 is as a selective and irreversible antagonist of PPARδ with pIC50 of 6.6, with no measurable affinity for hPPARα or hPPARγ |
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801312-28-7 |
GSK256066 |
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GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2. |
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