| CAS NO. |
Products Name |
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| 1799711-21-9 |
dBET1 |
more... |
| dBET1 is a potent BRD4 protein degrader based on PROTAC technology with an EC50 of 430 nM. dBET1 is a PROTAC that composes of (+)-JQ1 (HY-13030) linked to Thalidomide (HY-14658) with a linker |
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| 2230821-27-7 |
Gefitinib-based PROTAC 3 |
more... |
| Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively |
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| 1448297-52-6 |
(S,R,S)-AHPC |
more... |
| (S,R,S)-AHPC (MDK7526) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC (MDK7526) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[ |
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| 1950634-92-0 |
dBET6 |
more... |
| dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC50 of 14 nM, and has antitumor activity. |
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| 1061605-21-7 |
Thalidomide-O-COOH (Cereblon ligand 3) |
more... |
| Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs |
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