| CAS NO. |
Products Name |
| 668467-91-2 |
LDN-57444 |
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| LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3. |
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| 459168-41-3 |
JNJ7777120 |
more... |
| JNJ-7777120 is the first potent and selective non-imidazole histamine H4 receptor antagonist with Ki of 4.5 nM, exhibits >1000-fold selectivity over the other histamin receptors. |
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| 960374-59-8 |
ONX0914(PR-957) |
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| ONX-0914 (PR-957) is a potent and selective immunoproteasome inhibitor with minimal cross-reactivity for the constitutive proteasome. |
|
| 603139-19-1 |
Odanacatib (MK-0822) |
more... |
| Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3. |
|
| 147591-46-6 |
ID8 |
more... |
| ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. |
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| 847925-91-1 |
RO4929097 |
more... |
| RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. Phase 2. |
|
| 1146699-66-2 |
Avagacestat |
more... |
| Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
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