| CAS NO. |
Products Name |
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| 1217486-61-7 |
BYL719 |
more... |
| BYL719 is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, and minimal effect on PI3Kβ/γ/δ. Phase 2. |
|
| 371242-69-2 |
IC-87114 |
more... |
| IC-87114 is a selective PI3Kδ inhibitor with IC50 of 0.5 μM, 58-fold more selective for PI3Kδ than PI3Kγ, and over 100-fold more selective than PI3Kα/β. |
|
| 870281-82-6 |
CAL101 |
more... |
| CAL-101 (Idelalisib, GS-1101) is a selective p110δ inhibitor with IC50 of 2.5 nM; shown to have 40- to 300-fold greater selectivity for p110δ thanp110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR. Phase 3. |
|
| 371935-74-9 |
PI-103 |
more... |
| PI-103 is a multi-targeted PI3K inhibitor for p110α/β/δ/γ with IC50 of 2 nM/3 nM/3 nM/15 nM, less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM |
|
| 1246560-33-7 |
VS-5584 (SB2343) |
more... |
| VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively. Phase 1. |
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|
| 154447-36-6 |
LY294002 |
more... |
| LY294002 is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. |
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|
| 914913-88-5 |
Palomid 529 (P529) |
more... |
| Palomid 529 (P529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6 but no effect observed on pMAPK or pAktT308. Phase 1. |
|
| 1009298-59-2 |
AZD2014 |
more... |
| AZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM; highly selective against multiple PI3K isoforms (α/β/γ/δ). Phase 2. |
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