| CAS NO. |
Products Name |
| 326914-06-1 |
MHY1485 |
more... |
| MHY1485 is a mTOR activator; inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes leading to the accumulation of LC3II protein and enlarged autophagosomes. |
|
| 1394076-92-6 |
GNE-317 |
more... |
| GNE-317 is a potent PI3K/mTOR inhibitor that can cross the blood–brain barrier; shows potent suppression of the PI3K pathway in the brain of mice with intact BBB. |
|
| 934526-89-3 |
Pilaralisib (XL147) |
more... |
| Pilaralisib (XL147) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ with IC50 of 39 nM/36 nM/23 nM in cell-free assays, less potent to PI3Kβ. Phase 1/2. |
|
| 755038-65-4 |
Volasertib(BI6727) |
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| Volasertib (BI 6727) is a highly potent Plk1 inhibitor with IC50 of 0.87 nM in a cell-free assay. It shows 6- and 65-fold greater selectivity against Plk2 and Plk3. |
|
| 1608125-21-8 |
AMG319 |
more... |
| AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. |
|
| 1620576-64-8 |
AZD8835 |
more... |
| AZD8835 is a potent and selective inhibitor of PI3Kδ and PI3Kαwith IC50 of 5.7 nM and 6.2 nM, with selectivity against PI3Kβ (IC50 431 nM) and PI3Kγ (IC50 90 nM). |
|
| 1627494-13-6 |
AZD8186 |
more... |
| AZD8186 is a potent and selective inhibitor of PI3Kβ and PI3Kδ with IC50 of 4 nM and 12 nM, respectively. |
|
| 1608125-21-8 |
AMG319 |
more... |
| AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks |
|
| 1620576-64-8 |
AZD8835 |
more... |
| AZD8835 is an effective and selective PI3K inhibitors of PI3K and δ α, the IC50 values were 5.7 and 6.2 nM nM, selective than the PI3K-beta (IC50 to 431 nM) and PI3K gamma (IC50 for 90 nM). |
|
| 5142-23-4 |
3-Methyladenine (3-MA) |
more... |
| 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation. |
|
| 1276553-09-3 |
PF-4989216 |
more... |
| PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively. |
|
| 866405-64-3 |
BML-275 |
more... |
| Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK 6). |
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