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| All Products >>Akt // GSK-3 |
| CAS NO. |
Products Name |
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| 1616632-77-9 |
TIC10 |
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| TIC10(ONC-201) is a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier. |
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| 125314-13-8 |
CP21R7 |
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| CP21R7 is a potent and selective GSK-3β inhibitor. CP21R7 can inhibitor enhances the induction of KDR+precursors prior to vascular commitment.Cp21R7 compound induced the highest luciferase activity at a concentration of 3 μ M.[2] Immunofluorescence staining revealed that CP21 significantly increased total levels of intracellular ?-catenin. Activation of WNT signaling via GSK3 inhibition with CP21 induced commitment of hPSCs towards mesoderm. [ |
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| 125314-13-8 |
CP21R7 |
more... |
| CP21R7 is a potent and selective GSK-3β inhibitor. CP21R7 can inhibitor enhances the induction of KDR+precursors prior to vascular commitment.Cp21R7 compound induced the highest luciferase activity at a concentration of 3 μ M.[2] Immunofluorescence staining revealed that CP21 significantly increased total levels of intracellular ?-catenin. Activation of WNT signaling via GSK3 inhibition with CP21 induced commitment of hPSCs towards mesoderm. [3] |
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| 871361-88-5 |
SC66 |
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| SC66 is a novel AKT inhibitor, IC50 values of approximately 0.75 μg/ml at 72 hours in HepG2, HA22T/VGH and PLC/PRF/5 cells. IC50 value: 0.75 μg/ml (72 hours in HepG2, HA22T/VGH and PLC/PRF/5 cells) [1] Target: Akt in vitro: Each cell line had a different sensitivity to SC66, as evidenced by the IC50 values . HepG2, HA22T/VGH and PLC/PRF/5 cells had similar IC50 values of approximately 0.85 and 0.75 μg/ml at 48 and 72 hours, respectively. The most resistant cell line was Huh7, which showed an IC50 of 3.1 and 2.8 μg/ml at 48 and 72 hours respectively, while the Hep3B cell line was found to be the most sensitive, with an IC50 of 0.75 and 0.5 μg/ml at 48 and 72 hours, respectively. SC66 reducew cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in HCC cells. SC66 treatment led to a reduction in total and phospho-AKT levels. In addition, SC66 induces the production of reactive oxygen species (ROS) and DNA damage. SC66 significantly potentiates the effects of both conventional chemotherapeutic and targeted agents, doxorubicin and everolimus, respectively. [1] SC66 manifests a more effective growth suppression of transformed cells compared with other inhibitors of PIP3/Akt pathway. SC66 represents a unique chemical tool to investigate the mechanisms of ubiquitination-dependent Akt regulation in physiological and stressed conditions. SC66 directly facilitates Akt ubiquitination. [2] In vivo: SC66 inhibits tumor growth of Hep3B cells in xenograft models. [1] |
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| 1402608-02-9 |
BAY1125976 |
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| BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively. |
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| 1800070-77-2 |
Borussertib |
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| Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt |
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