| CAS NO. |
Products Name |
| 196868-63-0 |
PQ401 |
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| PQ401, a selective insulin-like growth factor-1 receptor blocker, is a novel diarylurea compound that inhibits IGF1R autophosphorylation with IC50 < 1 uM. |
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| 1454846-35-5 |
PF-06463922 |
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| PF-06463922 is a potent, dual ALK/ROS1 inhibitor with Ki of <0.02 nM, <0.07 nM, and 0.7 nM for ROS1, ALK (WT), and ALK (L1196M), respectively. Phase 1. |
|
| 1108743-60-7 |
Entrectinib |
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| Entrectinib(NMS-E628、RXDX-101) is an orally available ALK inhibitor; exhibits good activity against NPM–ALK with an IC50 value of 55 nM. |
|
| 1022958-60-6 |
CEP28122 |
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| CEP-28122 is a highly potent and selective orally active ALK inhibitor with IC50 of 1.9 ± 0.5 nM in an enzyme-based TRF assay. |
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| 1391712-60-9 |
CEP-37440 |
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| CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma). |
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| 1197953-54-0 |
Brigatinib |
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| Brigatinib is a highly potent and selective investigational ALK inhibitor with mean IC50 value ＜ 100 nM in Ba/F3 cells. |
|
| 1356962-34-9 |
HG-14-10-04 |
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| HG-14-10-04 is a potent and specific ALK inhibitor with IC50 of 20 nM. IC50 value: 20 nM Target: ALK More information can be found in the following Patent, Example 10 Preparation of substituted pyrimidinamines as ALK kinase inhibitors By Aquila, Brian; Kamhi, Victor; Peng, Bo; Pontz, Timothy; Saeh, Jamal Carlos; Thakur, Kumar; Yang, Bin From U.S. Pat. Appl. Publ. (2012), US 20120028924 A1 20120202 |
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| 1356962-20-3 |
AZD3463 |
more... |
| AZD-3463 is an ALK/IGF1R inhibitor which overcomes multiple mechanisms of acquired resistance to crizotinib. IC50 Value: Target: ALK/IGF1R |
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| 1802220-02-5 |
TPX-0005 |
more... |
| TPX-0005 is a potent ALK/ROS1/TRK inhibitor, with IC50 of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM for SRC, WT ALK, ALK G1202R and ALK L1196M, respectively. |
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