| CAS NO. |
Products Name |
| 511296-88-1 |
Pifithrin-β |
more... |
| Pifithrin-β HBr (Cyclic Pifithrin-α HBr) is a potent p53 inhibitor with IC50 of 23 uM in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1. |
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| 1431866-33-9 |
WEHI539 |
more... |
| WEHI-539, has high affinity (subnanomolar) and selectivity for BCL-XL and potently kills cells by selectively antagonizing its prosurvival activity. WEHI-539 has a high affinity for BCL-XL (IC50 = 1.1 nM). |
|
| 1262888-28-7 |
Spautin-1 |
more... |
| Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM. |
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| 1668553-26-1 |
A-1210477 |
more... |
| A-1210477 is a potent and selective MCL-1 inhibitor with Ki and IC50 of 0.454 nM and 26.2 nM, respectively, >100-fold selectivity over other Bcl-2 family members. |
|
| 1229705-06-9 |
RG7388 |
more... |
| RG7388 is an oral, selective, small molecule MDM2 antagonist that inhibits binding of MDM2 to p53. |
|
| 939981-39-2 |
RG7112 |
more... |
| RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. |
|
| 803647-40-7 |
NSC59984 |
more... |
| NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 μM for p53-null HCT116 cells. |
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| 1309684-94-3 |
RO8994 |
more... |
| RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). |
|
| 1313363-54-0 |
NVP-CGM097 |
more... |
| NVP-CGM097(CGM-097) is a potent and selective MDM2 inhibitor; an orally bioavailable HDM2 antagonist with potential antineoplastic activity. |
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