| CAS NO. |
Products Name |
| 193551-21-2 |
SB 239063 |
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| SB 239063 is a potent and selective p38 MAPK inhibitor (IC50 = 44 nM for p38α). SB 239063 displays > 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580. |
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| 874101-00-5 |
RO4987655(CH-4987655) |
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| RO4987655(CH-4987655) is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity. |
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| 303162-79-0 |
TAK-715 |
more... |
| TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1 |
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| 1550008-55-3 |
ML264 |
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| ML 264 is a potent Krüppel-like factor 5 (KLF5) inhibitor. ML264 inhibits the MAPK pathway by reducing EGR1 and KLF5 levels. ML 264 decreases proliferation of colorectal cancer cell lines, and inhibits the growth of xenografts in a mouse model of primary tumor development. |
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| 1236699-92-5 |
AS703026 |
more... |
| AS703026(Pimasertib) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 of 5 nM-2 μM in MM cell lines. |
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| 586379-66-0 |
PH-797804 |
more... |
| PH-797804 is an ATP-competitive, readily reversible inhibitor of the α isoform of human p38 MAP kinase, exhibiting a Ki = 5.8 nM. |
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| 869357-68-6 |
AZD8330 |
more... |
| AZD8330(ARRY-424704; ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. |
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| 449811-01-2 |
Pamapimod |
more... |
| Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor. Pamapimod inhibited p38α and p38β enzymatic activity, with IC50 values of 0.014 ± 0.002 and 0.48 ± 0.04 μM, respectively. Pamapimod is p38 inhibitor with IC50 of 0.06μM in THP-1 cell. |
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