| CAS NO. |
Products Name |
| 356559-20-1 |
SB525334 |
more... |
| SB525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6. |
|
| 446859-33-2 |
RepSox(E-616452; SJN 2511) |
more... |
| RepSox(E-616452; SJN 2511) is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. |
|
| 446859-33-2 |
RepSox |
more... |
| RepSox is a potent and selective inhibitor of the TGFβR-1/ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation in cell-free assays, respectively. |
|
| 1352608-82-2 |
EW-7197 |
more... |
| EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. |
|
| 521984-48-5 |
SIS3 |
more... |
| SIS3 is a potent and selective inhibitor of Smad3. a potent regulator of the human Nox4 promoter. |
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|
| 2141955-96-4 |
ALK2-IN-1 |
more... |
| ALK2-IN-1 is a activin receptor-like kinase-2 (ALK2) inhibitor extracted from patent WO2017181117A1, Compound 876, has an IC50 of <10 nM |
|
| 452342-67-5 |
GW788388 |
more... |
| GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor. |
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