| CAS NO. |
Products Name |
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| 1361224-53-4 |
AMG-3969 |
more... |
| AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM. |
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| 125314-13-8 |
CP21R7 |
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| CP21R7 is a potent and selective GSK-3β inhibitor. CP21R7 can inhibitor enhances the induction of KDR+precursors prior to vascular commitment.Cp21R7 compound induced the highest luciferase activity at a concentration of 3 μ M.[2] Immunofluorescence staining revealed that CP21 significantly increased total levels of intracellular ?-catenin. Activation of WNT signaling via GSK3 inhibition with CP21 induced commitment of hPSCs towards mesoderm. [ |
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| 1252594-99-2 |
ETP-46321 |
more... |
| ETP-46321 is a potent and orally bioavailable PI3K α/δ inhibitor with IC50 of 2.3/14.2 nM for p110α/p110β; exhibits potency on mutated p110α(IC50=1.77-2.33 nM, p110a E542K; E545K; H1047R). IC50 value: 2.3/14.2 nM(p110α/p110β) Target: PI3K α/δ inhibitor ETP-46321, has been pro?led and shown to be a potent PI3K a and d inhibitor, highly selective versus mTOR and 288 representative kinases. The compound demonstrated a good pharmacokinetic profile in mice and was selected for preliminary in vivo evaluation in a lung tumor mouse model driven by a K-Ras G12V oncogenic mutation, showing significant tumor growth inhibition (ca. 51%), and reduction of the tumor metabolic activity as measured by PET techniques. |
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| 1334719-95-7 |
Q203 |
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| Q203 (IAP6) is a midazopyridine amide compound. Q203 is active against Mycobacterium tuberculosis H37Rv with an MIC50 of 2.7 nM in culture broth medium. |
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| 1361224-53-4 |
AMG-3969 |
more... |
| AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4 nM. |
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